MERCK 1.105794.0001 Tlc Silica Gel Glass Plates 60 F254 HX87076394

( Brand: Merck ), ( Manufacturer Part Number: 1.105794.0001 ), ( Model: 1.105794.0001 HX87076394 ), ( Part Type: Plate ), ( Unit Quantity: Package Of 100 ), ( Country Of Origin: Germany ), ( Intended Use/discipline: Medical Laboratory, Physical Laboratory )

Review MERCK Tlc Silica Gel 60 100 Glass Plates

Merck s **1.105794.0001 TLC Silica Gel 60 F Glass Plates (HX87076394)** represent a premium choice for thin-layer chromatography (TLC), engineered to deliver unparalleled precision, consistency, and reliability for both academic and industrial applications. These high-quality glass-backed plates feature a uniform layer of **silica gel 60** (particle size 0.063 0.200 mm), a standard grade optimized for optimal separation efficiency across a wide range of analytes, including organic compounds, pharmaceuticals, natural products, and synthetic intermediates. The **F ** designation indicates the presence of a fluorescent indicator (typically 254 nm excitation wavelength), enabling highly sensitive visualization of separated components under UV light even at trace concentrations as the silica gel absorbs UV radiation while the sample spots fluoresce against a dark background. The plates are pre-coated with a chemically inert, tightly bound silica gel layer, ensuring minimal bleeding, tailing, or interference during development, which is critical for reproducible and accurate results. With dimensions of **20 cm 20 cm 1 mm** (thickness), these plates offer ample surface area for multi-sample analysis while maintaining structural integrity during handling, solvent development, and post-development processing. The glass backing provides exceptional durability, resistance to warping, and compatibility with a broad spectrum of mobile phases, including polar and non-polar solvents, as well as aqueous systems. Additionally, the plates are pre-activated and ready for immediate use, eliminating the need for pre-treatment steps that can introduce variability. Whether employed for routine quality control, method development, or advanced analytical research, Merck s **1.105794.0001** plates exemplify the brand s commitment to quality, ensuring consistent performance, minimal background interference, and the ability to resolve complex mixtures with exceptional clarity. Their compatibility with standard TLC chambers, derivatization reagents, and detection methods further solidifies their role as a versatile and indispensable tool in chromatographic analysis.

**Pros and Cons of Buying Merck 1.105794.0001 TLC Silica Gel 60 F254 Glass Plates (HX87076394)**

1. **High Quality and Reliability** Merck is a well-established brand in analytical chemistry, known for producing high-purity silica gel plates that provide consistent results for thin-layer chromatography (TLC). The F254 indicator ensures uniform fluorescence for visualization under UV light.

2. **Standardized Performance** The 60 F254 designation indicates a particle size of 15 40 m and a layer thickness of 0.25 mm, which is ideal for most separation applications. The pre-activated plates are ready for immediate use, reducing preparation time.

3. **Versatility** These plates are suitable for a wide range of applications, including organic synthesis, pharmaceutical analysis, natural product separation, and quality control testing. The glass backing provides durability and stability during development.

4. **UV Detection** The F254 fluorescent indicator allows for clear visualization of separated compounds under UV light (254 nm), improving detection sensitivity compared to non-fluorescent plates.

5. **Consistent Layer Thickness** The uniform 0.25 mm layer ensures reproducible migration distances and separation efficiency, which is critical for quantitative and qualitative analysis.

6. **Compatibility with Common Solvents** The silica gel is chemically stable and works well with a variety of mobile phases, including polar and non-polar solvents.

7. **Long Shelf Life** Properly stored (in a sealed container with desiccant), these plates maintain their performance for extended periods, reducing the need for frequent replacements.

8. **Brand Reputation** Merck is trusted in academic and industrial labs for its adherence to strict quality control standards, minimizing batch-to-batch variability.

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1. **Cost** Compared to generic or lower-quality TLC plates, Merck plates are more expensive. For high-throughput or budget-sensitive applications, this may be a significant drawback.

2. **Fragility** Glass-backed plates are more prone to breakage than plastic or aluminum-backed alternatives, which can be inconvenient in fieldwork or large-scale applications.

3. **Storage Requirements** The plates must be stored in a dry, sealed environment to prevent moisture absorption, which can degrade separation performance. Improper storage may lead to uneven activation or reduced fluorescence.

4. **Waste Generation** Glass plates generate more waste compared to disposable plastic or aluminum-backed plates, which may be less environmentally friendly in high-volume labs.

5. **Limited Customization** Unlike some brands, Merck does not offer extensive customization options for layer thickness or particle size for this specific product line, restricting flexibility for specialized applications.

6. **Shipping Sensitivity** Glass plates are fragile during shipping, requiring careful handling to avoid damage. Delays or mishandling could result in unusable plates upon arrival.

7. **Activation Time** While pre-activated, some users report that further activation (e.g., heating in an oven) may be required for optimal performance, adding an extra step to the workflow.

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Merck 1.105794.0001 TLC silica gel plates are a premium choice for labs prioritizing reliability, reproducibility, and high-resolution separations. Their standardized quality, UV detectability, and compatibility with diverse solvent systems make them ideal for research, pharmaceutical, and analytical applications where precision is critical. However, the higher cost, fragility, and storage requirements may not justify their use in cost-sensitive or high-volume settings where disposable alternatives suffice.

For **academic research, pharmaceutical development, or quality control in regulated industries**, these plates are strongly recommended due to their proven performance and consistency. For **routine or large-scale industrial use**, a cost-benefit analysis is advisable considering whether the added expense aligns with the specific needs of the application.

If budget is a constraint, alternatives like **Macherey-Nagel or other reputable brands** may offer comparable performance at a lower cost, though Merck remains the gold standard for critical applications. Always verify the specific requirements of your workflow before purchasing.

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• brand: Merck
• mpn: 1.105794.0001
• model: 1.105794.0001 Hx87076394
• part type: Plate
• unit quantity: Package Of 100
• country of origin: Germany
• intended use/discipline: Medical Laboratory, Physical Laboratory

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