PALL 4457T Acrodisc Lc Syringe Filters Pvdf Membrane 13MM 0.45 100/PK

( Brand: Pall ), ( Manufacturer Part Number: 4457T ), ( Part Type: Filter ), ( Unit Quantity: 100 ), ( Country Of Origin: United States )

Review PALL Acrodisc Lc 13mm Syringe Filters Pvdf Membrane 0.45 Sealed 100/pk

The **Pall 4457T Acrodisc LC 13mm Syringe Filter with a 0.45-micron PVDF Membrane** is a high-performance, single-use filtration solution designed for precise and reliable sample preparation in laboratory and industrial applications. Engineered with Pall s proprietary **Acrodisc** technology, this filter combines a robust **polyvinylidene difluoride (PVDF)** membrane with a durable polypropylene housing, delivering exceptional chemical resistance, low protein binding, and superior flow rates. The **0.45-micron pore size** ensures effective removal of bacteria, particulates, and larger contaminants while maintaining high recovery rates for analytes, making it ideal for applications such as **liquid chromatography (LC), sample clarification, cell culture media sterilization, and pharmaceutical processing**. The **13mm diameter** provides a generous filtration surface area, reducing clogging and enhancing throughput, while the **low extractables and leachables profile** ensures compatibility with sensitive biological and chemical samples. Each filter is individually packaged in a **sterile, non-pyrogenic format**, guaranteeing contamination-free performance for critical applications. Whether used in **HPLC, GC, or bioprocessing workflows**, this filter offers a dependable balance of efficiency, durability, and sterility, making it a trusted choice for laboratories demanding consistent and reproducible results.

### **Pros and Cons of Buying Pall 4457T Acrodisc LC 13mm Syringe Filters (PVDF Membrane, 0.45 m, 100/Pk)**

1. **High Quality and Reliability** Pall is a well-established manufacturer in filtration technology, known for producing durable and consistent filters. The Acrodisc LC series is designed for laboratory and industrial applications, ensuring reliable performance.

2. **PVDF Membrane Advantages** Polyvinylidene fluoride (PVDF) is chemically resistant to a wide range of solvents, acids, and bases, making these filters suitable for aggressive or corrosive samples. It also has a low protein-binding capacity, reducing sample contamination.

3. **Low Protein Binding** The PVDF membrane minimizes adsorption of proteins and other biomolecules, which is critical for preserving sample integrity in biological and pharmaceutical applications.

4. **Sterility and Contamination Control** The filters are pre-sterilized (typically gamma-irradiated), reducing the risk of microbial contamination in sensitive applications like cell culture, drug formulation, or sample preparation.

5. **Compatibility with a Wide Range of Applications** The 0.45 m pore size is ideal for removing bacteria, particulates, and large molecules while allowing smaller molecules (e.g., salts, small peptides) to pass through. This makes them versatile for filtration of aqueous solutions, buffers, and organic solvents.

6. **Convenient Syringe Filter Design** The 13mm diameter fits standard syringe filters, making them easy to use with laboratory syringes. The Acrodisc housing is durable and prevents membrane damage during use.

7. **Cost-Effective for Bulk Purchases** Buying in bulk (100/pk) reduces per-unit cost, making them economical for frequent use in laboratories or production settings.

8. **Compatibility with Autoclaving (If Needed)** Unlike some membranes, PVDF can withstand autoclaving under certain conditions, though Pall s specifications should be checked for exact limits.

9. **Good Flow Rate** The membrane design provides a reasonable flow rate for syringe filtration, reducing processing time compared to some alternative filters.

10. **Regulatory Compliance** Pall products are often used in pharmaceutical, biotech, and medical applications where compliance with standards (e.g., USP, ISO) is required. These filters are likely to meet such regulations.

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1. **Higher Upfront Cost** Compared to generic or lower-end syringe filters, Pall s Acrodisc LC filters are more expensive. This may be a drawback for small-scale or budget-conscious users.

2. **Limited Solvent Compatibility (Relative to PTFE)** While PVDF is highly resistant, it may not be as universally compatible with extreme solvents (e.g., some strong oxidizing agents) as PTFE (Teflon) membranes. PTFE filters are often preferred for highly aggressive solvents.

3. **Potential for Membrane Damage** If not handled carefully, the PVDF membrane can tear or delaminate from the housing, especially if the filter is forced through a syringe with excessive pressure. This can compromise sterility and filtration efficiency.

4. **Disposal Considerations** PVDF filters are not biodegradable and should be disposed of as hazardous waste if they come into contact with toxic or infectious materials, which may add to operational costs.

5. **Flow Rate Limitations with High-Viscosity Samples** Like most syringe filters, performance degrades with highly viscous samples (e.g., oils, thick suspensions), leading to slower filtration or clogging.

6. **Not Reusable** Syringe filters are single-use only, which increases waste generation and requires frequent replacement.

7. **Potential for Leakage** If the filter housing is damaged or improperly sealed, leakage can occur, contaminating the sample or the environment.

8. **Storage Requirements** The filters should be stored properly (e.g., in a cool, dry place) to prevent degradation of the membrane or housing material.

9. **Alternative Options May Be Cheaper** For non-critical applications, generic or brand-name filters (e.g., from Millipore, Nalgene, or local suppliers) may offer similar performance at a lower cost.

10. **Training or Experience Needed** Proper use (e.g., correct pressure, orientation, and disposal) requires some familiarity with syringe filtration techniques, which may not be intuitive for inexperienced users.

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The **Pall 4457T Acrodisc LC 13mm syringe filters (PVDF, 0.45 m)** are a high-quality, chemically resistant, and reliable choice for laboratory and industrial filtration applications where sample integrity and sterility are critical. Their PVDF membrane offers excellent resistance to a wide range of solvents and low protein binding, making them ideal for biological, pharmaceutical, and analytical work. The bulk packaging (100/pk) provides cost savings for frequent users, and the syringe filter design ensures ease of use.

However, the higher cost compared to generic alternatives and potential limitations with extreme solvents or high-viscosity samples may make them less suitable for cost-sensitive or non-critical applications. Users should also ensure proper handling to avoid membrane damage or contamination.

- You require high chemical resistance, low protein binding, and sterility in applications like cell culture, drug formulation, or sample preparation.

- You frequently filter large volumes or need bulk supplies for laboratory or production use.

- Compliance with pharmaceutical or biotech standards (e.g., USP, ISO) is mandatory.

- You prioritize reliability and brand reputation over cost savings.

- Your budget is tight, and generic filters (e.g., Millipore or Nalgene) meet your needs.

- You frequently filter highly aggressive solvents (PTFE filters may be more suitable).

- The application is non-critical (e.g., simple aqueous filtrations where cost is a major concern).

For most **high-demand laboratory or pharmaceutical applications**, the **Pall 4457T filters are a strong recommendation** due to their performance and reliability. For other uses, a cost-benefit analysis against alternatives is advisable.

Details:

Sealed container. Pall part # 4457T. New old stock. Free Shipping.

This listing is for a SEALED 100 filters container of Acrodisc LC 13mm Syringe Filter with 0.45 um PVDF Membrane.

part #: 4457t prices

• $63.75-$69.99

specifications plasticwarelabsuppy:

• brand: Pall
• mpn: 4457t
• part type: Filter
• unit quantity: 100
• country of origin: United States

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• # reviews: 76
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• rating: 100.0%

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• started: May 3, 2026
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• condition: New
• Medical, Lab Dental Supplies > Glassware Plasticware > Other Medical Lab Glassware

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