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KIMBLE 885300-0000 Kontes Tissue Grinder Dounce Pestles Tube Design 0.5

885300-0000 Kimble Kontes Tissue Grinder Dounce 0.5 Ml 2 Pestles And Tube Design

( Brand: Kimble ), ( Manufacturer Part Number: 885300-0000 ), ( Part Type: Grinder Tube ), ( Unit Type: Unit ), ( Intended Use/discipline: Biological Laboratory, Microbiological Laboratory, Physical Laboratory )

Review KIMBLE Kontes Tissue Grinder Dounce 0.5 Ml Pestles And Tube Design

The **Kimble Kontes Tissue Grinder (Model 885300-0000)** is a precision-engineered laboratory tool designed for efficient and gentle homogenization of soft biological tissues, cells, and delicate samples. Crafted from high-quality borosilicate glass with a durable, heat-resistant construction, this Dounce-style homogenizer ensures reliable performance while minimizing shear stress on sensitive materials. The **0.5 mL tube design** is ideal for small-scale applications, such as cell culture processing, tissue dissociation, or sample preparation in molecular biology, immunology, and microbiology. Its **tight-fitting, ground-glass pestle** provides a smooth, controlled grinding action, reducing cell lysis and preserving sample integrity compared to mechanical homogenizers. The ergonomic, dual-chamber design allows for easy sample loading and thorough mixing, while the clear glass construction enables visual monitoring of the homogenization process. Perfect for laboratories requiring consistency and reproducibility, this tissue grinder is compatible with a wide range of biological and biochemical workflows, including RNA/DNA extraction, protein isolation, and cell lysis. Its durable, reusable construction makes it a cost-effective alternative to disposable homogenizers, while its compatibility with standard laboratory glassware ensures seamless integration into existing workflows. Whether used in research, clinical diagnostics, or educational settings, the Kontes Tissue Grinder delivers precise, low-shear homogenization for optimal sample preparation.

### **Pros and Cons of the Kimble Kontes Tissue Grinder (885300-0000) with Dounce 0.5 Pestles (Tube Design)**

#### **Pros:**

1. **Durability and Quality Construction** The Kontes brand is known for producing high-quality, long-lasting laboratory glassware. The tissue grinder is made from borosilicate glass, which is resistant to thermal shock and chemical corrosion, making it suitable for repeated use in demanding applications.

2. **Efficient Tissue Homogenization** The Dounce-style pestle design provides a tight seal with the tube, allowing for effective disruption of cells or tissues. This is particularly useful for preparing samples for DNA/RNA extraction, protein lysis, or other biochemical assays where gentle yet thorough homogenization is required.

3. **Compatibility with Common Laboratory Tubes** The 0.5 mL tube design fits standard microcentrifuge tubes (e.g., 1.5 mL or 2 mL tubes can be adapted with adapters), making it versatile for small-scale experiments. This is ideal for molecular biology, cell biology, and biochemistry labs working with limited sample volumes.

4. **Easy to Clean and Sterilize** Glass components can be thoroughly cleaned with detergents, autoclaved, or baked for sterilization, reducing contamination risks. Unlike plastic homogenizers, glass does not leach chemicals over time.

5. **Precision Fit and Sealing** The pestle fits snugly into the tube, minimizing sample leakage during homogenization. This is critical for maintaining sample integrity, especially in experiments where precise volume control is necessary.

6. **Cost-Effective for Long-Term Use** While the initial cost may be higher than disposable plastic homogenizers, the durability of the Kontes grinder makes it a cost-effective choice over time, particularly in high-throughput or academic settings where disposables would be prohibitively expensive.

7. **Wide Range of Applications** Beyond tissue homogenization, this grinder can be used for:

- Cell lysis (for protein or nucleic acid extraction).

- Breaking open yeast, bacteria, or plant cells.

- Preparing samples for PCR, Western blotting, or other downstream analyses.

- Gentle disruption of delicate biological samples without shearing DNA/RNA.

8. **Compatibility with Automated Systems** Some versions of the Kontes grinder can be adapted for use with motorized homogenizers (e.g., the Kontes Pellet Pestle system), though the basic manual version relies on manual force.

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#### **Cons:**

1. **Manual Labor Intensive** The basic model requires manual force to operate the pestle, which can be tiring for large numbers of samples. This may not be ideal for high-throughput workflows unless combined with a motorized adapter.

2. **Potential for Glass Breakage** Despite its durability, borosilicate glass can still crack or shatter if dropped or subjected to excessive force. This risk is higher with glassware than with plastic alternatives, though proper handling minimizes it.

3. **Limited to Small Volumes** The 0.5 mL tube design restricts its use to micro-scale applications. Larger tissue samples may require multiple homogenization steps or a different grinder (e.g., a larger Dounce homogenizer or a motorized homogenizer like the Omni TH).

4. **Learning Curve for Optimal Use** Achieving consistent homogenization without shearing DNA/RNA or lysing cells requires practice. Over-aggressive homogenization can degrade samples, while insufficient homogenization may leave cells intact, reducing yield.

5. **Not Ideal for Very Hard or Abrasive Samples** While effective for soft tissues, the Kontes grinder may struggle with very hard or fibrous samples (e.g., plant stems, certain types of bacteria, or calcified tissues). In such cases, a different homogenization method (e.g., bead beating or a motorized homogenizer) may be necessary.

6. **Maintenance and Replacement Parts** Over time, the pestle may wear out or become damaged. While Kontes offers replacement pestles, this adds to the long-term cost. Plastic alternatives may not last as long but are cheaper to replace.

7. **Space Requirements** The grinder and tubes take up storage space, which may be a consideration in labs with limited bench space.

8. **Potential for Contamination** If not cleaned thoroughly between uses, glassware can harbor residual samples or contaminants. While glass is easier to sterilize than some plastics, improper cleaning can still introduce carryover.

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### **Conclusion:**

The Kimble Kontes Tissue Grinder (885300-0000) with Dounce 0.5 Pestles is a **high-quality, versatile tool** for small-scale tissue and cell homogenization in laboratory settings. Its durability, precision, and compatibility with common microcentrifuge tubes make it a reliable choice for molecular biology, cell biology, and biochemistry applications. However, its manual operation, limited volume capacity, and potential for glass breakage are drawbacks that must be weighed against its advantages.

For labs prioritizing **gentle yet effective homogenization of small samples**, this grinder is an excellent investment. It is particularly well-suited for:

- DNA/RNA extraction from cells or tissues.

- Protein lysis for Western blotting or ELISA.

- Preparing samples for PCR or sequencing.

- Gentle cell disruption without shearing nucleic acids.

For labs requiring **high throughput, large-volume homogenization, or automated processing**, a motorized homogenizer (e.g., Omni TH, BeadBeater, or a larger Dounce homogenizer) may be more appropriate. Additionally, if working with **extremely hard or fibrous samples**, a different homogenization method may be necessary.

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### **Recommendation:** **Buy the Kimble Kontes Tissue Grinder (885300-0000) if:**

- You work with **small volumes (0.5 1.5 mL) of soft tissues or cells**.

- You need a **durable, reusable, and easy-to-clean** homogenization tool.

- Your workflow involves **gentle lysis for nucleic acid or protein extraction**.

- You are willing to invest in **high-quality glassware** for long-term use.

**Consider alternatives if:**

- You require **high-throughput or automated homogenization** (e.g., motorized homogenizers).

- Your samples are **very hard or fibrous** (e.g., plant stems, bones, or certain bacteria).

- You frequently work with **larger volumes** (>1.5 mL) and need a scalable solution.

- Budget constraints make disposable plastic homogenizers more feasible.

For most **molecular biology or cell biology labs handling small-scale samples**, the Kontes grinder is a **strong recommendation** due to its balance of performance, durability, and versatility. Pair it with proper training on homogenization techniques to maximize efficiency and sample integrity.

Details:

This Listing Is For One 1 New Kimble Kontes Tissue Grinder Dounce 0.5 ML 2 Pestles Tube Design.

part #: 8853000000 price

  • $129.99

specifications plasticwarelabsuppy:

  • brand: Kimble
  • mpn: 885300-0000
  • part type: Grinder Tube
  • unit type: Unit
  • intended use/discipline: Biological Laboratory, Microbiological Laboratory, Physical Laboratory

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  • quantity: 2
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  • started: April 29, 2026

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part type: grinder tube, unit type: unit, intended use/discipline: biological laboratory, microbiological laboratory, physical laboratory,
category: business & industrial > medical, lab dental supplies > glassware plasticware > medical lab glassware, sku: 13771026973909603,
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