CHEMGLASS CG-1860-14 Glass Frit Solid Phase Peptide Vessel 250ML Synthesis
( Brand: Chemglass ), ( Manufacturer Part Number: CG-1860-14 ), ( Intended Use/discipline: Biological Laboratory, Dental Laboratory, Medical Laboratory, Microbiological Laboratory, Physical Laboratory ), ( Unit Type: Unit ), ( Country Of Origin: United States ), ( Additional Information: Surplus Laboratory Consumable Supplies )
Review CHEMGLASS Glass 250ml Frit Solid Phase Peptide Synthesis Vessel
The **Chemglass CG-1860-14 Glass 250 mL Frit Solid Phase Peptide Synthesis (SPPS) Vessel** is a meticulously engineered laboratory component designed to elevate the precision and efficiency of solid-phase peptide synthesis. Crafted from high-quality borosilicate glass, this vessel is built to withstand the rigorous demands of peptide synthesis, offering exceptional chemical resistance, thermal stability, and durability. Its robust construction ensures compatibility with a wide range of solvents, reagents, and reaction conditions, making it an indispensable tool for researchers and chemists working in peptide chemistry, biochemistry, or related fields.
The vessel features a **250 mL capacity**, providing ample space for scalable peptide synthesis while maintaining optimal reaction volumes for consistent results. The **frit base** is a defining characteristic, serving as a critical filtration and support system that allows for efficient resin bead retention during synthesis cycles. This design minimizes resin loss during washing and coupling steps, ensuring that the peptide synthesis process remains streamlined and reproducible. The frit s uniform pore structure promotes even flow distribution, reducing clogging and facilitating thorough washing of the resin bed without disrupting the synthesis workflow.
Beyond its functional advantages, the CG-1860-14 is engineered with **ergonomic and practical considerations** in mind. The vessel s **wide-mouth design** allows for easy loading and unloading of resin, while its **standard taper joint** ensures compatibility with a variety of glassware accessories, including funnels, adapters, and vacuum manifolds. This versatility makes it an ideal component for integration into automated or semi-automated peptide synthesis systems, as well as manual procedures. The vessel s **clear borosilicate glass** provides visual clarity, enabling researchers to monitor reaction progress, resin bed uniformity, and solvent levels throughout the synthesis process.
Safety and ease of use are paramount in laboratory settings, and the CG-1860-14 excels in both areas. The vessel is **autoclavable and chemically inert**, ensuring that it can be sterilized for repeated use without degradation or contamination. Its **smooth, polished surface** reduces the risk of residue buildup, simplifying cleaning and maintenance. Additionally, the vessel s **secure sealing mechanism** prevents leaks during high-vacuum or pressurized operations, safeguarding both the user and the integrity of the synthesis process. Whether employed in academic research, pharmaceutical development, or industrial applications, this vessel delivers reliability and performance, making it a cornerstone of modern peptide synthesis workflows.
The **Chemglass CG-1860-14 Glass 250 mL Frit Solid Phase Peptide Synthesis (SPPS) Vessel** is a specialized piece of laboratory glassware designed for peptide synthesis. Below is a detailed breakdown of its pros and cons, followed by a conclusion and recommendation.
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### **Pros**
1. **Material Quality and Durability**
The vessel is made of borosilicate glass, which is chemically resistant, thermally stable, and less prone to cracking or breaking compared to standard soda-lime glass. This makes it suitable for repeated use in peptide synthesis, where solvents and reagents can be harsh.
2. **Frit Design for Efficient Filtration**
The integrated frit (glass frit) at the bottom allows for easy filtration of reaction mixtures without the need for external filtration apparatus. This simplifies workflows, especially when washing resins or collecting peptides after synthesis. The frit prevents loss of resin during decanting and ensures that only the filtrate is removed.
3. **Scalability and Versatility**
The 250 mL capacity is large enough for small-to-medium-scale peptide synthesis (e.g., gram quantities), making it useful for both research and small-scale production. It can accommodate various resin types (e.g., Rink amide MBHA, Wang resin) and is compatible with standard SPPS protocols.
4. **Compatibility with Common SPPS Reagents**
Borosilicate glass is inert to most organic solvents (e.g., DMF, DCM, NMP), acids (e.g., TFA), and bases used in peptide synthesis. This reduces the risk of contamination or degradation of the peptide product.
5. **Easy to Clean and Sterilize**
Glass vessels are easier to clean thoroughly compared to plastic or metal alternatives. They can be washed with solvents, sonicated, and sterilized by autoclaving or baking, which is critical for maintaining sterile conditions in peptide synthesis.
6. **Visual Clarity**
The transparency of glass allows for easy monitoring of reaction progress, color changes, or the presence of suspended solids (e.g., resin beads). This is particularly useful for troubleshooting or assessing reaction completeness.
7. **Compatibility with Standard SPPS Equipment**
The vessel s design is compatible with common SPPS accessories, such as syringes, pipettes, and automated synthesizers (if adapted). The threaded or sealed lid (if included) ensures a secure fit to prevent leaks during agitation or filtration.
8. **Long-Term Investment**
High-quality glassware like this is a durable investment that can last for years with proper care. It avoids the need for frequent replacements, which can be costly over time.
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### **Cons**
1. **Fragility Compared to Plastic or Metal**
While borosilicate glass is more durable than standard glass, it is still susceptible to thermal shock (e.g., rapid temperature changes) or mechanical damage (e.g., dropping). This requires careful handling, especially when using hot solvents or during filtration under vacuum.
2. **Weight and Bulkiness**
Glass vessels are heavier than plastic alternatives, which can make them less convenient for frequent transport or use in field settings. They also occupy more storage space compared to compact plastic containers.
3. **Potential for Contamination**
Even with borosilicate glass, there is a risk of trace metal contamination (e.g., from glass impurities) if the vessel is not properly cleaned or if harsh reagents (e.g., strong acids) are used excessively. This can be mitigated by using glassware specifically designed for peptide synthesis and thorough cleaning protocols.
4. **Cost**
High-quality glassware like this is more expensive upfront compared to generic glassware or plastic alternatives. However, the long-term durability often justifies the cost for frequent users.
5. **Limited Reusability with Certain Resins**
Some resins or peptides may adhere strongly to the glass surface, requiring aggressive cleaning (e.g., prolonged sonication with strong solvents). In extreme cases, this could shorten the vessel s lifespan or necessitate replacement.
6. **Threaded Lid Compatibility**
If the vessel requires a threaded lid (not always included), compatibility with standard SPPS lids may vary. Some users may need to purchase additional accessories, adding to the cost.
7. **Not Ideal for High-Pressure Applications**
While designed for standard SPPS, the vessel is not suitable for high-pressure or vacuum applications beyond typical filtration. Over-vacuuming could risk damaging the frit or the vessel itself.
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### **Conclusion**
The **Chemglass CG-1860-14 Glass 250 mL Frit SPPS Vessel** is an excellent choice for laboratories or researchers engaged in solid-phase peptide synthesis. Its borosilicate construction, efficient frit design, and compatibility with standard SPPS protocols make it a reliable and versatile tool. The vessel s durability and inertness to common reagents ensure consistent performance over time, while its transparency and ease of cleaning enhance workflow efficiency.
However, its fragility, weight, and higher cost compared to alternatives may be drawbacks for some users. The decision to purchase this vessel depends on the scale of your work, budget, and specific requirements for peptide synthesis. If you prioritize quality, durability, and ease of use in a research or production setting, this vessel is highly recommended. For smaller-scale or budget-conscious applications, alternatives like plastic SPPS vessels or smaller glass vessels may suffice.
### **Recommendation**
For **research laboratories, academic institutions, or small-scale peptide production**, the **Chemglass CG-1860-14** is an outstanding investment. Its combination of quality, functionality, and compatibility with standard SPPS protocols makes it a practical choice for users who need reliable performance and ease of use.
If you are working on a **tight budget** or require **portability**, consider evaluating alternatives like:- **Plastic SPPS vessels** (e.g., from Chemglass or other manufacturers) for cost savings and reduced weight.
- **Smaller glass vessels** (e.g., 50 mL or 100 mL) if your scale of synthesis is lower.
For **large-scale or industrial peptide synthesis**, you may also consider **custom or specialized vessels** with additional features (e.g., reinforced frits, larger capacities).
Ultimately, if your workflow involves frequent or critical peptide synthesis, the **Chemglass CG-1860-14** is a well-justified purchase that will serve you well for years with proper care.
Details:
No other chips or cracks throughout. See pictures for details. Chip on top outside lip 5mm, can't be felt inside, doesn't effect thread. GSR veers 1730 GS 9.9.4 1730 Used item in great condition.
part #: cg186014 prices
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- brand: Chemglass
- mpn: Cg-1860-14
- intended use/discipline: Biological Laboratory, Dental Laboratory, Medical Laboratory, Microbiological Laboratory, Physical Laboratory
- unit type: Unit
- country of origin: United States
- additional information: Surplus Laboratory Consumable Supplies
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- started: February 13, 2026
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- Medical, Lab Dental Supplies > Glassware Plasticware > Other Medical Lab Glassware
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