CHEMGLASS SY-0408-102JS Tef Stpk Frit Solid Phase Peptide 4000ML GL-45 4MM Synthesis Vessel

( Brand: Chemglass ), ( Manufacturer Part Number: SY-0408-102JS ), ( Intended Use/discipline: Biological Laboratory, Dental Laboratory, Medical Laboratory, Microbiological Laboratory, Physical Laboratory ), ( Unit Type: Unit ), ( Country Of Origin: United States ), ( Additional Information: Surplus Laboratory Consumable Supplies )

Review CHEMGLASS 4000ml 4mm Tef Stpk Frit Solid Phase Peptide Synthesis Vessel

The **Chemglass SY-0408-102JS 4000 mL GL-45 4 mm Teflon -Backed Solid Phase Peptide Synthesis (SPPS) Vessel** is a high-performance, precision-engineered reactor designed specifically for the demanding requirements of modern solid-phase peptide synthesis (SPPS). Crafted from durable borosilicate glass (Type I, chemically resistant) with a robust **GL-45 ground glass joint**, this vessel ensures an airtight, leak-proof seal that maintains sterile conditions throughout synthesis cycles, eliminating contamination risks while allowing for easy assembly and disassembly. The **4000 mL capacity** provides ample volume for large-scale peptide production, accommodating substantial resin loads and reagent volumes without compromising efficiency or safety. The **4 mm Teflon -backed frit** at the base serves as a critical filtration and support system, ensuring uniform resin distribution, efficient solvent drainage, and gentle, clog-free flow during washing and elution steps critical for preserving peptide integrity and yield. The vessel s **Teflon -coated interior** further enhances its resistance to aggressive solvents, acids, and bases commonly used in SPPS, such as trifluoroacetic acid (TFA), dimethylformamide (DMF), and dichloromethane (DCM), while preventing resin adhesion and simplifying cleanup. Its **stainless steel support plate (STPK)** reinforces structural stability, reducing the risk of breakage during vigorous mixing or centrifugation, and the **magnetic stirring compatibility** allows for precise, homogeneous mixing of resin and reagents, optimizing reaction kinetics. Ideal for both academic research and industrial-scale peptide synthesis, this vessel combines durability, chemical inertness, and functional versatility, making it an indispensable tool for chemists seeking reliable, high-yield peptide synthesis with minimal manual intervention.

**Pros and Cons of buying a Chemglass SY-0408-102JS 4000 mL GL-45 4 mm Teflon-Supported Polypropylene (TSPK) Frit Solid Phase Peptide Synthesis (SPPS) Vessel**

### **Pros**

1. **High Capacity and Versatility** The 4000 mL volume is ideal for large-scale peptide synthesis, allowing for significant batch production without frequent transfers or scaling up across multiple vessels. This is particularly useful for research labs, academic institutions, or industrial settings where efficiency is critical.

2. **Durability and Chemical Resistance** The vessel is constructed from **polypropylene (PP)**, a material known for its resistance to most organic solvents, acids, and bases commonly used in SPPS. The **Teflon-supported polypropylene (TSPK) frit** ensures compatibility with harsh reagents while maintaining structural integrity, reducing the risk of contamination or degradation over time.

3. **Efficient Filtration and Resin Handling** The **4 mm frit** provides a balance between flow rate and particle retention, preventing resin leakage during synthesis, washing, or cleavage steps. This minimizes manual intervention and reduces the risk of losing valuable resin or product.

4. **Standardized GL-45 Connections** The **GL-45 ground glass joint** allows for easy attachment to syringes, pumps, or other SPPS accessories, facilitating automated or semi-automated workflows. This standardization simplifies setup and integration with existing lab equipment.

5. **Compatibility with Automated Systems** Many modern peptide synthesizers and automated SPPS rigs are designed to work with GL-45 vessels. This makes the unit suitable for labs transitioning from manual to automated synthesis, improving reproducibility and reducing human error.

6. **Low Protein Binding** Polypropylene and Teflon-coated surfaces are less prone to non-specific protein adsorption, which is beneficial when working with sensitive peptides or proteins that could otherwise degrade or lose activity due to surface interactions.

7. **Cost-Effective for Large-Scale Work** While the initial cost may be higher than smaller vessels, the **4000 mL capacity** reduces the need for multiple smaller units, lowering long-term operational expenses. It also minimizes solvent and reagent waste per unit volume.

8. **Easy Cleaning and Maintenance** The smooth, non-porous surface of polypropylene is straightforward to clean with solvents like methanol, acetone, or detergent solutions. The frit can be backwashed or replaced if necessary, extending the vessel s lifespan.

9. **Compatibility with Common SPPS Reagents** The material is resistant to standard SPPS reagents, including **DMF, DCM, TFA, and DIEA**, ensuring that the vessel can withstand the full synthesis cycle without degradation.

10. **Safety and Leak-Proof Design** The **Teflon frit** and secure GL-45 joint reduce the risk of leaks during high-pressure or vacuum operations, enhancing safety in the lab.

---

### **Cons**

1. **High Initial Cost** Compared to smaller or less specialized vessels, the **4000 mL GL-45 TSPK frit model** is relatively expensive. This may be a barrier for small labs, startups, or individual researchers working on a limited budget.

2. **Bulkiness and Storage Challenges** The large size makes storage and transportation cumbersome. It requires more space on benchtops or in fume hoods, which may not be feasible in compact labs.

3. **Weight and Handling Difficulties** Filled with solvent or resin, the vessel can be **heavy and difficult to maneuver**, especially for single-handed operation. This may require additional support or assistance during transfers.

4. **Limited Compatibility with Some Automated Systems** While many automated synthesizers support GL-45 vessels, some newer or specialized systems may require **custom adapters or different fittings**, potentially adding complexity or cost.

5. **Potential for Resin Clogging** Over time, **fine resin particles or impurities** can accumulate in the frit, reducing flow efficiency. While the 4 mm frit is designed to handle most SPPS resins, very fine or highly cross-linked resins (e.g., some Merrifield-type supports) may still pose clogging risks.

6. **Not Ideal for Microscale or Pilot Studies** If a lab primarily conducts **small-scale or exploratory synthesis**, the oversized vessel may be underutilized, leading to inefficiencies in reagent usage and workspace organization.

7. **Potential for Teflon Degradation Over Time** While Teflon is highly durable, **prolonged exposure to strong oxidizing agents (e.g., certain cleavage cocktails or excessive heat)** could theoretically degrade the frit over many years, requiring eventual replacement.

8. **Learning Curve for New Users** Operating a large-scale SPPS vessel requires familiarity with **flow rates, backpressure, and resin bed management**, which may be unfamiliar to researchers transitioning from manual or smaller-scale methods.

9. **Limited Availability of Replacement Parts** While Chemglass offers support, **frit replacements or GL-45 joints may not be as readily available** as generic labware, potentially causing delays if maintenance is needed.

10. **Not Suitable for All Solvents** While polypropylene resists most SPPS solvents, **highly polar or ionic solvents (e.g., some aqueous buffers)** may still pose compatibility concerns, though this is rare in standard SPPS workflows.

---

### **Conclusion**

The **Chemglass SY-0408-102JS 4000 mL GL-45 4 mm Teflon-Supported Polypropylene SPPS vessel** is a **high-quality, large-scale solution** for peptide synthesis, offering **superior durability, efficiency, and compatibility** with automated systems. Its **chemical resistance, filtration reliability, and scalability** make it an excellent choice for **research labs, academic institutions, and industrial settings** where large-volume synthesis is required.

However, the **high cost, bulkiness, and specialized nature** of the vessel may not be justified for **small-scale or exploratory work**. Researchers should carefully consider their **synthesis volume, budget, and workflow needs** before purchasing.

If **large-scale, high-throughput peptide synthesis** is a priority and if the lab has the **space, budget, and expertise** to handle it effectively this vessel is a **strong recommendation**. For smaller operations or those still optimizing protocols, a **smaller vessel (e.g., 100 500 mL) or a multi-well format** might be more practical.

### **Final Recommendation**

- You require **large-scale (4 L ) peptide synthesis** for research, production, or teaching.

- Your lab uses **automated SPPS systems** compatible with GL-45 fittings.

- You prioritize **durability, chemical resistance, and minimal resin loss** during synthesis.

- Your workspace and budget can accommodate the **size and cost** of the vessel.

- You primarily work with **small-scale or pilot batches** (opt for 100 500 mL vessels instead).

- Your lab lacks **space for large equipment** or **experience with high-volume synthesis**.

- You need **frequent solvent or reagent changes** that may stress the Teflon frit over time.

- Budget constraints make this vessel **unaffordable** compared to smaller, equally effective options.

For most **serious peptide chemists or production labs**, this vessel is a **worthwhile investment** that enhances efficiency and reduces operational bottlenecks.

Details:

Old stock that appears new, but listing as used since no original box included. GSR veers 1730 GS 9.9.4 1730 Item in excellent condition with little to no signs of use. See pictures for details.

part #: sy0408102js prices

• $54.99-$185.99

specifications plasticwarelabsuppy:

• brand: Chemglass
• mpn: Sy-0408-102js
• intended use/discipline: Biological Laboratory, Dental Laboratory, Medical Laboratory, Microbiological Laboratory, Physical Laboratory
• unit type: Unit
• country of origin: United States
• additional information: Surplus Laboratory Consumable Supplies

offer plasticwarelabsuppy:

• availability: In Stock
• sold: 0
• options: Ship-to-home
• quantity: 2
• started: February 12, 2026

returns plasticwarelabsuppy:

• paid by: Seller
• method: Money back
• policy: Returns Accepted
• time: 30 Days

general plasticwarelabsuppy:

• condition: Used
• Medical, Lab Dental Supplies > Glassware Plasticware > Other Medical Lab Glassware

seller plasticwarelabsuppy:

• city: Cotati, California
• # reviews: 7414
• rating: 99.8%

shipping plasticwarelabsuppy:

• service: Standard
• cost: $0.00
• type: Fixed
• transit: 5-9 Days
• class: Standard

payments plasticwarelabsuppy:

• other
• wallet: Apple-pay
• credit card: Discover

Chemglass SY-0408-102JS Is Similar To:

• 5-neck Chemglass Reaction Vessel Neck Lid Center Side Schott Flange (27.5% similar) Chemglass reaction vessel 5 neck lid 45 50, 4 sides with 200MM Scott flange no chips, cracks or breaks. They are based on package size, weight and buyers zip code. I have quite a lot of lab chemistry glass available, if you don't see here, just ask and will check my inventory. Glass is clear with no...(November 8th, 2018)
• Cg-1866-05 Chemglass Glass Ml Solid Phase Peptide Synthesis Vessel Medium Frit (58.5% similar) Medium frit, vacuum, t-bore PDF stopcock, 24 40 outer joint.: cg Chemglass cat. No chips, cracks. A used Chemglass 250 ml glass solid phase peptide synthesis vessel in very good condition...(September 30th, 2018)
• Cg-3002-l-14 Chemglass 14 Solid Ptfe (34.1% similar) Thorough cleaning and sterilization are recommended before use used glassware will show signs of wear sometimes including light scratches, discoloration, stickers tape, or exterior markings. Size: 14, 14 20 joint - PDF stopper has a polypropylene extraction nut permitting easy removal of the from ...(November 30th, 2017)
• Cg-3003-02 60725 Chemglass Safe-lab 14-20 Joint Solid (30.1% similar) Brand: Chemglass, safe-lab part: cg, 60725 joint: 14 20 material: solid PDF Teflon - autoclave safe at 121 c f new old stock used glassware will show signs of wear sometimes including residue, light scratches, stickers tape or exterior markings...(March 6th, 2017)
• Chemglass Cg-1866-06 500ml Peptide Synthesis Vessel Solid Phase Vacuum Medium (50.6% similar) Power cords and power adapters are never included unless specifically mentioned. Cleaned with acetone prior to listing. This unit will arrive in the condition shown. Chemglass CG-1866-06 500ML peptide synthesis vessel solid phase vacuum medium: this lot is for one Chemglass peptide synthesis vessel...(November 18th, 2023)
• Chemglass Cg-1946-06 500ml Cylindrical Reaction Vessel 100mm Schott Flange Cg-1920-01 (40.4% similar) No chips, scratches or cracks. 100MM Short flange. GSR veers 1608 gs 9.5 1608 used like new. X 135MM height...(January 13th, 2024)
• Chemglass Cg-1920-02 1000ml Cylindrical Reaction Vessel 100mm Schott O-ring Flange Cg192002 (41.3% similar) X 210MM height . 100MM Short flange. Slight chips on ring, no scratches, cracks or staining. GSR veers 1608 gs 9.5 1608 excellent used condition...(January 20th, 2024)
• Chemglass Cg-1864-01 Peptide Synthesis Vessels 10ml Medium Frit No Stopcock (45.9% similar) Of both lower stems is 8MM. Warranty this item is guaranteed to be as described. This unit will arrive in the condition shown. Orders are shipped to the cardholders billing address. Lower stopcock is a bore 2MM PDF to allow nitrogen be used upwardly agitate the resin beads while shaking. Top of the ...(January 22nd, 2024)
• Chemglass Cg-1864-02 Peptide Synthesis Vessels 25ml Medium Frit No Stopcock (45.9% similar) On the ask a question link at bottom of this listing. Of both lower stems is 8MM. Shipping buyer pays for all shipping costs. Solid phase peptide synthesis vessel having a medium porosity, gritted glass resin support. Power cords and power adapters are never included unless specifically mentioned. ...(January 23rd, 2024)
• Chemglass Cg-1880-22 35 Ml Hw Pressure Vessel Cylindrical 15 Internal Thread (34.1% similar) Warranty this item is guaranteed to be as described. Chemglass CG-1880-22 35ML Haw pressure vessel cylindrical #15 internal thread: this lot is for one Chemglass 35 ml pressure vessel. This unit will arrive in the condition shown. On the ask a question link at bottom of this listing. Orders are ...(January 24th, 2024)
• Chemglass Cg-1860-01 Peptide Synthesis Vessel 10ml Solid Phase Med Frit Gl-14 (45.9% similar) Lower PDF stopcock has a 2MM bore with the arm being 8MM.D. Top of the vessel has a gl thread and is supplied complete with PDF lined Pvt screw cap. Peptide synthesis vessels, solid phase: solid phase peptide synthesis vessel having a medium or coarse porosity gritted glass resin support...(January 28th, 2024)