
( Brand: Chemglass ), ( Manufacturer Part Number: SY-0502-182JS ), ( Intended Use/discipline: Biological Laboratory, Dental Laboratory, Medical Laboratory, Microbiological Laboratory, Physical Laboratory ), ( Unit Type: Unit ), ( Country Of Origin: United States ), ( Additional Information: Surplus Laboratory Consumable Supplies )
The **Chemglass SY-0502-182JS 200 mL 24/40 Joint Solid Phase Peptide Synthesis (SPPS) Vessel with 4 mm Teflon -Backed Solid Support Frit** is a precision-engineered reaction vessel meticulously designed for the demanding requirements of modern solid-phase peptide synthesis (SPPS). Crafted from high-quality borosilicate glass (Type 1, Class A), this vessel combines exceptional chemical resistance, thermal stability, and optical clarity to ensure reliable performance across a wide range of synthetic protocols. The **24/40 standard taper joint** facilitates seamless compatibility with a vast array of laboratory glassware, including syringes, filters, and other SPPS accessories, while the **4 mm Teflon -backed solid support frit** provides an efficient and reusable filtration system, preventing clogging and ensuring smooth resin flow during washing and coupling steps. The **200 mL working volume** offers ample capacity for scalable peptide synthesis while maintaining optimal reagent-to-resin ratios, and the **threaded cap with PTFE-lined septum** ensures an airtight, contamination-free environment, critical for sensitive peptide synthesis. Ideal for both manual and automated SPPS workflows, this vessel is engineered to withstand repeated use in harsh organic solvents, strong acids, and bases, making it a durable and versatile tool for researchers, chemists, and laboratories focused on high-purity peptide production. Its robust construction and thoughtful design features such as the reinforced joint and secure sealing mechanism minimize the risk of leaks or breakage, while the **Teflon -backed frit** enhances resin retention and simplifies post-reaction filtration without compromising peptide integrity. Whether employed in routine synthesis or advanced peptide engineering, this vessel delivers the precision, reliability, and ease of use required to achieve high-yield, high-quality results in every synthesis cycle.
**Pros and Cons of buying a Chemglass SY-0502-182JS 200mL 24/40 4mm Teflon-SPK Frit Solid Phase Peptide Synthesis (SPPS) Vessel**
### **Pros:**1. **High-Quality Construction** The vessel is made from borosilicate glass (likely Type 1 or 3.3), which is chemically resistant, durable, and suitable for harsh organic solvents and acidic/basic conditions commonly used in peptide synthesis.
2. **Teflon-Coated Interior** The Teflon (PTFE) coating reduces adsorption of peptides and reagents, minimizing losses and improving yield. It also prevents contamination from glass surfaces, which is critical in peptide synthesis where purity is essential.
3. **SPK Frit Design** The solid-phase support (SPK) frit allows for efficient filtration and washing of resin while retaining it within the vessel. This is ideal for solid-phase peptide synthesis (SPPS), where repeated washing steps are necessary.
4. **Standard 24/40 Joint** The ground-glass joint ensures a secure, leak-proof seal when connected to other glassware (e.g., funnels, adapters, or reactors). This compatibility is valuable for setting up complex workflows.
5. **Thick-Walled (4mm)** The 4mm wall thickness provides structural integrity, reducing the risk of breakage during vigorous mixing, heating, or cooling (e.g., during coupling/deprotection steps).
6. **Capacity and Size** The 200mL volume is suitable for small-to-medium-scale peptide synthesis (e.g., gram quantities), balancing cost and reagent usage without being overly cumbersome.
7. **Compatibility with SPPS Workflows** The design aligns with standard SPPS protocols, including resin loading, coupling, deprotection, and cleavage steps. The frit ensures resin remains in place during filtration.
8. **Reusable and Long-Lasting** High-quality glassware like this is designed for repeated use, making it a cost-effective investment over time, especially in academic or industrial settings.
9. **Easy to Clean** The smooth Teflon coating and glass surface can be thoroughly cleaned with solvents (e.g., acetone, methanol, or dilute acids/bases), reducing cross-contamination risks.
10. **Manufacturer Reputation** Chemglass is a well-regarded supplier of laboratory glassware, known for precision, reliability, and adherence to pharmaceutical/biochemical standards.
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### **Cons:**1. **Cost** Compared to disposable or lower-quality vessels, this item represents a significant upfront investment. For one-time or small-scale use, the cost may not justify the purchase.
2. **Breakage Risk** Despite the thick walls, glassware can still break if dropped or subjected to thermal shock (e.g., rapid heating/cooling). This is a general risk with glassware, though proper handling mitigates it.
3. **Maintenance Requirements** The Teflon coating and glass must be cleaned thoroughly after each use to prevent residue buildup, which can affect subsequent reactions. Neglecting cleaning may lead to contamination or reduced performance.
4. **Limited Flexibility for Non-SPPS Uses** While versatile for SPPS, the frit design may not be ideal for other applications (e.g., general organic synthesis without filtration needs), making it less adaptable than a standard round-bottom flask.
5. **Storage Space** The vessel occupies more space than disposable alternatives, which may be a consideration in labs with limited storage.
6. **Potential for Leaks** Over time, the ground-glass joint may wear out or develop leaks if not handled carefully. Regular inspection and maintenance are required to ensure a tight seal.
7. **Not Ideal for High-Pressure Reactions** Like all glassware, this vessel is not designed for high-pressure conditions (e.g., microwave-assisted synthesis under pressure). It is strictly for atmospheric or low-pressure applications.
8. **Alternative Options May Exist** For very large-scale or specialized applications, other vessels (e.g., polypropylene reactors with integrated filters) might offer advantages in terms of cost, durability, or ease of use.
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### **Conclusion:**The **Chemglass SY-0502-182JS 200mL 24/40 Teflon-SPK Frit SPPS Vessel** is a high-quality, specialized tool tailored for solid-phase peptide synthesis. Its Teflon coating, frit design, and borosilicate construction make it an excellent choice for researchers or labs performing routine or medium-scale peptide synthesis where yield, purity, and reproducibility are critical. The investment is justified for long-term use in academic, industrial, or pharmaceutical settings where cost per use is amortized over multiple projects.
However, for occasional users, small-scale work, or applications outside SPPS, the cost and maintenance requirements may outweigh the benefits. In such cases, disposable alternatives or simpler glassware might be more practical.
### **Recommendation:** - **Buy if:**- You are engaged in **solid-phase peptide synthesis** and require a durable, high-yield vessel.
- You prioritize **purity, reproducibility, and long-term use** over disposable convenience.
- Your workflow involves **frequent washing, filtration, and resin handling**, where the frit design is advantageous.
- You have the **budget and storage space** for quality glassware.
- **Consider alternatives if:**- You are a **student or researcher** with limited funding and infrequent need for SPPS.
- You require **larger volumes or high-pressure reactions**, which may necessitate different equipment.
- You prefer **disposable or polypropylene vessels** for cost or convenience, even if they lack the precision of glass.
For most **serious peptide chemists or labs**, this vessel is a worthwhile purchase due to its reliability and performance. For others, weighing the cost against usage frequency is essential.
New old stock. GSR veers 1730 GS 9.9.4 1730 See pictures for details.